Blow-Fill-Seal, commonly abbreviated as BFS, is an advanced technology at Novopharm that guarantees an automated process in which plastic containers (ampoules) are blown, filled, and sealed in a sterile and continuous manner.

BFS technology supports patient safety by offering practical, single-use sterile containers that eliminate the need for preservatives and is recognized by the FDA (US Food and Drug Administration) as a high-end sterile process, for the production of injections/eye drops.

BFS vials are specifically tailored for various pharmaceutical formulations, including solutions, suspensions, gels and emulsions.

There are 3 main stages to produce a product using BFS technology:

Blow: Virgin plastic particles are put into the machine, heated under a temperature of over 160 degrees Celsius and a pressure of 35MPa. Sterile air is blown in, forming a mold for the product packaging.

Fill: The pump pours liquid into the packaging to the correct, full pre-programmed dose.

Seal: After pouring enough dose, the injection pliers are pulled out and the mold is sealed.